The impact of the effective dose to immune cells on lymphopenia and survival of esophageal cancer after chemoradiotherapy.

ABSTRACT:

Purpose

To test the hypothesis that effective dose to circulating immune cells (EDIC) impacts the severity of radiation-induced lymphopenia and clinical outcomes of esophageal cancer patients treated with concurrent chemoradiotherapy (CCRT).

Material and methods

488 esophageal cancer patients treated with CCRT with and without surgery were analyzed. The EDIC model considers the exposure of circulating immune cells as the proportion of blood flow to lung, heart, liver, and the volume of the exposed area of the body, with the basis of mean lung dose (MLD), mean heart dose (MHD), mean liver dose (MlD), and integral dose (ITD) of the body region scanned, calculated as: EDIC=0.12∗MLD+0.08∗MHD+0.15∗0.85∗MlD∗n45^1/2+0.45+0.35∗0.85∗nk^1/2∗ITD62∗10³ Whe

SUBMITTER: Xu C 

PROVIDER: S-EPMC7506523 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature