Obesity, estrogens and adipose tissue dysfunction - implications for pulmonary arterial hypertension.

ABSTRACT: Obesity is a prevalent global public health issue characterized by excess body fat. Adipose tissue is now recognized as an important endocrine organ releasing an abundance of bioactive adipokines including, but not limited to, leptin, adiponectin and resistin. Obesity is a common comorbidity amongst pulmonary arterial hypertension patients, with 30% to 40% reported as obese, independent of other comorbidities associated with pulmonary arterial hypertension (e.g. obstructive sleep apnoea). An 'obesity paradox' has been observed, where obesity has been associated with subclinical right ventricular dysfunction but paradoxically may confer a protective effect on right ventricular function once pulmonary hypertension develops. Obesity and pulmonary arterial hypertension share multiple pathophys

SUBMITTER: Mair KM 

PROVIDER: S-EPMC7506791 | biostudies-literature | 2020 Jul-Sep

REPOSITORIES: biostudies-literature