FARP-1 deletion is associated with lack of response to autism treatment by early start denver model in a multiplex family.

ABSTRACT:

Background

Children with autism spectrum disorder (ASD) display impressive clinical heterogeneity, also involving treatment response. Genetic variants can contribute to explain this large interindividual phenotypic variability.

Methods

Array-CGH (a-CGH) and whole genome sequencing (WGS) were performed on a multiplex family with two small children diagnosed with ASD at 17 and 18 months of age. Both brothers received the same naturalistic intervention for one year according to the Early Start Denver Model (ESDM), applied by the same therapists, yielding dramatically different treatment outcomes.

Results

The older sibling came out of the autism spectrum, while the younger sibling displayed very little, in any, improvement. This boy was subsequently treated applying a str

SUBMITTER: Cucinotta F 

PROVIDER: S-EPMC7507005 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature