Cytogenetic and FISH analysis of 93 multiple myeloma Moroccan patients.

ABSTRACT:

Background

Multiple myeloma (MM) is a disease characterized by heterogeneous clinical presentations as well as complex genetic and molecular abnormalities. In MM, cytogenetic analysis is a challenge because of the low proliferation of malignant plasma cells. Thus, interphase fluorescence in situ hybridization (FISH), performed on sorted plasma cells detected abnormalities independently of a proliferative and infiltrative index. The purpose of this study was to explore, for the first time, the cytogenetic and molecular genetics features in Moroccan patients with multiple myeloma referred exclusively to National Reference Laboratory and to determine their risk stratification based on these features.

Methods

We performed cytogenetic analysis on 93 MM cases, all patients were su

SUBMITTER: Hamdaoui H 

PROVIDER: S-EPMC7507047 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature