Determinants of suboptimal CD4⁺ T cell recovery after antiretroviral therapy initiation in a prospective cohort of acute HIV-1 infection.

ABSTRACT:

Introduction

Up to 30% of individuals treated with antiretroviral therapy (ART) during chronic HIV fail to recover CD4 counts to >500 cells/mm³ despite plasma viral suppression. We investigated the frequency and associations of suboptimal CD4 recovery after ART started during acute HIV infection (AHI).

Methods

Participants who started ART in Fiebig I to V AHI with ≥48 weeks of continuous documented HIV-RNA < 50 copies/mL were stratified by CD4 count at latest study visit to suboptimal immune recovery (SIR; CD4 < 350 cells/mm³ ), intermediate immune recovery (IIR; 350 ≤ CD4 < 500) and complete immune recovery (CIR; CD4 ≥ 500). Clinical and laboratory parameters were assessed at pre-ART baseline and latest study visit. Additional inflammatory and neurobeh

SUBMITTER: Handoko R 

PROVIDER: S-EPMC7507109 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature