Genetic risk for Alzheimer disease in children: Evidence from early-life IQ and brain white-matter microstructure.

ABSTRACT: It remains unclear whether the genetic risk for late-onset Alzheimer disease (AD) is linked to premorbid individual differences in general cognitive ability and brain structure. The objective of the present study was to determine whether the genetic risk of late-onset AD is related to premorbid individual differences in intelligence quotient (IQ) and characteristics of the cerebral white-matter in children. The study sample included children of the Generation R Study from Rotterdam, The Netherlands. IQ was measured using a well-validated Dutch nonverbal IQ test (n = 1908) at ages 5 to 9 years. White-matter microstructure was assessed by measuring fractional anisotropy (FA) of white-matter tracts using diffusion tensor imaging (DTI) (n = 919) at ages 9 to 12 years. Genetic risk was quantifi

SUBMITTER: Vinueza-Veloz MF 

PROVIDER: S-EPMC7507145 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature