Impact of Phenol-Enriched Virgin Olive Oils on the Postprandial Levels of Circulating microRNAs Related to Cardiovascular Disease.

ABSTRACT:

Scope

We investigate the postprandial modulation of cardiovascular-related microRNAs elicited by extra virgin olive oil (EVOOs) containing different levels of their own polyphenols.

Methods and results

It is randomized, postprandial, parallel, double-blind study. Twelve healthy participants consumed 30 mL of EVOO containing low (L-EVOO; 250 mg total phenols kg^-1 of oil), medium (M-EVOO; 500 mg total phenols kg^-1 of oil), and high (H-EVOO; 750 mg total phenols kg^-1 of oil) enriched EVOOs. Postprandial plasma microRNAs levels are analyzed by real-time quantitative PCR. The results show that L-EVOO intake is associated with decreased let-7e-5p and miR-328a-3p levels and increased miR-17-5p and miR-20a-5p, concentrations. M-EVOO decreases plasma

SUBMITTER: Daimiel L 

PROVIDER: S-EPMC7507201 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature