Pyruvate-lactate exchange and glucose uptake in human prostate cancer cell models. A study in xenografts and suspensions by hyperpolarized [1-¹³ C]pyruvate MRS and [¹⁸ F]FDG-PET.

ABSTRACT: Reprogramming of energy metabolism in the development of prostate cancer can be exploited for a better diagnosis and treatment of the disease. The goal of this study was to determine whether differences in glucose and pyruvate metabolism of human prostate cancer cells with dissimilar aggressivenesses can be detected using hyperpolarized [1-¹³ C]pyruvate MRS and [¹⁸ F]FDG-PET imaging, and to evaluate whether these measures correlate. For this purpose, we compared murine xenografts of human prostate cancer LNCaP cells with those of more aggressive PC3 cells. [1-¹³ C]pyruvate was hyperpolarized by dissolution dynamic nuclear polarization (dDNP) and [1-¹³ C]pyruvate to lactate conversion was followed by ¹³ C MRS. Subsequently [¹⁸

SUBMITTER: van Heijster FHA 

PROVIDER: S-EPMC7507209 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature