Iterative sure independent ranking and screening for drug response prediction.

ABSTRACT:

Background

Prediction of drug response based on multi-omics data is a crucial task in the research of personalized cancer therapy.

Results

We proposed an iterative sure independent ranking and screening (ISIRS) scheme to select drug response-associated features and applied it to the Cancer Cell Line Encyclopedia (CCLE) dataset. For each drug in CCLE, we incorporated multi-omics data including copy number alterations, mutation and gene expression and selected up to 50 features using ISIRS. Then a linear regression model based on the selected features was exploited to predict the drug response. Cross validation test shows that our prediction accuracies are higher than existing methods for most drugs.

Conclusions

Our study indicates that the features selected by the marg

SUBMITTER: An B 

PROVIDER: S-EPMC7507262 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature