Multi-omics profiling highlights lipid metabolism alterations in pigs fed low-dose antibiotics.

ABSTRACT:

Background

In order to study the relations of hepatocellular functions, weight gain and metabolic imbalance caused by low-dose antibiotics (LDA) via epigenetic regulation of gene transcription, 32 weaned piglets were employed as animal models and randomly allocated into two groups with diets supplemented with 0 or LDA (chlorotetracycline and virginiamycin).

Results

During the 4 weeks of the experiment, LDA showed a clear growth-promoting effect, which was exemplified by the significantly elevated body weight and average daily gain. Promoter methylome profiling using liquid hybridization capture-based bisulfite sequencing (LHC-BS) indicated that most of the 745 differential methylation regions (DMRs) were hypermethylated in the LDA group. Several DMRs were significantly enric

SUBMITTER: Hu Y 

PROVIDER: S-EPMC7507292 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature