Porous Pt Nanospheres Incorporated with GOx to Enable Synergistic Oxygen-Inductive Starvation/Electrodynamic Tumor Therapy.

ABSTRACT: Glucose-oxidase (GOx)-mediated starvation by consuming intracellular glucose has aroused extensive exploration as an advanced approach for tumor treatment. However, this reaction of catalytic oxidation by GOx is highly dependent on the on-site oxygen content, and thus starvation therapy often suffers unexpected anticancer outcomes due to the intrinsic tumorous hypoxia. Herein, porous platinum nanospheres (pPts), incorporated with GOx molecules (PtGs), are synthesized to enable synergistic cancer therapy. In this system, GOx can effectively catalyze the oxidation of glucose to generate H₂O₂, while pPt triggers the decomposition of both endogenous and exogenous H₂O₂ to produce considerable content of O₂ to facilitate the glucose consumpt

SUBMITTER: Lu Z 

PROVIDER: S-EPMC7507307 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature