Utility of plasma neurofilament light and total tau for clinical trials in Alzheimer's disease.

ABSTRACT:

Introduction

Several blood-based biomarkers are associated with neuronal injury, but their utility in interventional clinical trials is unclear. This study retrospectively evaluated the utility of plasma neurofilament light (NfL) and total tau (t-tau) in an 18-month trial in mild Alzheimer's disease (AD).

Methods

Correlation and conditional independence analyses and Gaussian graphical models were used to investigate cross-sectional and longitudinal relations between NfL, t-tau, and clinical scales.

Results

NfL had a stronger association than t-tau with clinical scales; t-tau did not hold additional information to that given by NfL (P > 0.05 at all time points). NfL held independent information about shorter-term (3- to 6-month) progression beyond patient age an

SUBMITTER: Raket LL 

PROVIDER: S-EPMC7507310 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature