Complex IV subunit isoform COX6A2 protects fast-spiking interneurons from oxidative stress and supports their function.

ABSTRACT: Parvalbumin-positive (PV⁺ ) fast-spiking interneurons are essential to control the firing activity of principal neuron ensembles, thereby regulating cognitive processes. The high firing frequency activity of PV⁺ interneurons imposes high-energy demands on their metabolism that must be supplied by distinctive machinery for energy generation. Exploring single-cell transcriptomic data for the mouse cortex, we identified a metabolism-associated gene with highly restricted expression to PV⁺ interneurons: Cox6a2, which codes for an isoform of a cytochrome c oxidase subunit. Cox6a2 deletion in mice disrupts perineuronal nets and enhances oxidative stress in PV⁺ interneurons, which in turn impairs the maturation of their morphological and functional prop

SUBMITTER: Sanz-Morello B 

PROVIDER: S-EPMC7507454 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature