Genetic determinants of circulating galectin-3 levels in patients with coronary artery disease.

ABSTRACT:

Background

Galectin-3 plays a crucial role in the regulation of inflammation. The aim of this study was to elucidate the association between LGALS3 genotypes, galectin-3 levels, and inflammatory marker levels in patients with coronary artery disease (CAD).

Results

A total of 474 patients with CAD were enrolled. Significant correlations were discerned between galectin-3 levels and leukocyte counts, C-reactive protein, soluble intercellular adhesion molecule-1, and matrix metalloproteinase 9 levels (all p < .05). The LGALS3 rs2274273, rs4644, rs4652 genotypes, and haplotypes CAC, CCC, and ACT exhibited a significant association with galectin-3 levels (for genotypes, p = 1.05 × 10^-25 , 3.54 × 10^-25 , and 2.74 × 10^-7 , respectively). Multivariate

SUBMITTER: Liao YH 

PROVIDER: S-EPMC7507567 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature