Pro-inflammatory HDL in women with obesity and nonalcoholic steatohepatitis.

ABSTRACT:

Background

Individuals with non-alcoholic fatty liver disease (NAFLD), which includes non-alcoholic steatohepatitis (NASH), are at increased risk for cardiovascular events, independent of traditional risk factors. Limited data on pro-inflammatory high density lipoprotein (HDL) in NASH exists in the literature. We hypothesized that HDL from individuals with NASH would be more pro-inflammatory than HDL from individuals without NASH.

Methods

Study participants were individuals with obesity who had undergone bariatric surgery with wedge liver biopsy. Using HDL isolated from serum obtained from study participants at the time of surgery, HDL-elicited macrophage cytokine expression (TNF-α, IL-1β, and IL-6) from THP-1 macrophages, HDL-associated receptor expression (ABCA1 and ABCG1)

SUBMITTER: Sarkar S 

PROVIDER: S-EPMC7507596 | biostudies-literature | 2020 Jul - Aug

REPOSITORIES: biostudies-literature