Effects of propofol and sevoflurane on hepatic blood flow: a randomized controlled trial.

ABSTRACT:

Background

Maintaining adequate perioperative hepatic blood flow (HBF) supply is essential for preservation of postoperative normal liver function. Propofol and sevoflurane affect arterial and portal HBF. Previous studies have suggested that propofol increases total HBF, primarily by increasing portal HBF, while sevoflurane has only minimal effect on total HBF. Primary objective was to compare the effect of propofol (group P) and sevoflurane (group S) on arterial, portal and total HBF and on the caval and portal vein pressure during major abdominal surgery. The study was performed in patients undergoing pancreaticoduodenectomy because - in contrast to hepatic surgical procedures - this is a standardized surgical procedure without potential anticipated severe hemodynamic disturbance

SUBMITTER: van Limmen J 

PROVIDER: S-EPMC7507611 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature