Development and validation of a cancer stem cell-related signature for prognostic prediction in pancreatic ductal adenocarcinoma.

ABSTRACT:

Background

Cancer stem cells (CSCs) are crucial to the malignant behaviour and poor prognosis of pancreatic ductal adenocarcinoma (PDAC). In recent years, CSC biology has been widely studied, but practical prognostic signatures based on CSC-related genes have not been established or reported in PDAC.

Methods

A signature was developed and validated in seven independent PDAC datasets. The MTAB-6134 cohort was used as the training set, while one local Chinese cohort and five other public cohorts were used for external validation. CSC-related genes with credible prognostic roles were selected to form the signature, and their predictive performance was evaluated by Kaplan-Meier survival, receiver operating characteristic (ROC), and calibration curves. Correlation analysis was emp

SUBMITTER: Feng Z 

PROVIDER: S-EPMC7507616 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature