Age and APOE genotype affect the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease.

ABSTRACT:

Background

Electrophysiological studies show that reductions in power within the alpha band are associated with the Alzheimer's disease (AD) continuum. Physical activity (PA) is a protective factor that has proved to reduce AD risk and pathological brain burden. Previous research has confirmed that exercise increases power in the alpha range. However, little is known regarding whether other non-modifiable risk factors for AD, such as increased age or APOE ε4 carriage, alter the association between PA and power in the alpha band.

Methods

The relationship between PA and alpha band power was examined in a sample of 113 healthy adults using magnetoencephalography. Additionally, we explored whether ε4 carriage and age modulate this association. The correlations between alpha powe

SUBMITTER: de Frutos-Lucas J 

PROVIDER: S-EPMC7507658 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature