The expression and regulation of HOX genes and membrane proteins among different cytogenetic groups of acute myeloid leukemia.

ABSTRACT:

Background

The cytogenetic aberrations were considered as markers for diagnosis and prognosis in acute myeloid leukemia (AML), while the expression and regulation under different cytogenetic groups remain to be fully elucidated.

Methods

In this paper, for favorable, poor, and cytogenetically normal groups of AML patients, we performed comprehensive bioinformatics analyses including identifying differentially expressed genes (DEGs) and microRNAs (miRNAs) among them, functional enrichment and regulatory networks.

Results

We found that DEGs were enriched in membrane-related processes. Eleven genes and two miRNAs were significantly differentially expressed among these three AML groups. In survival analysis, membrane-related genes and several miRNAs were significant on pro

SUBMITTER: Wang H 

PROVIDER: S-EPMC7507697 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature