Role of IgM testing in the diagnosis and post-treatment follow-up of syphilis: a prospective cohort study.

ABSTRACT:

Objectives

The diagnosis of repeat syphilis and its follow-up remains challenging. We aimed to investigate if IgM testing may assist in the diagnosis of syphilis reinfection/relapse and its treatment follow-up.

Methods

This substudy was conducted in the context of a syphilis biomarker discovery study (ClinicalTrials.gov Nr: NCT02059525). Sera were collected from 120 individuals with a new diagnosis of syphilis (72 with repeat infections) and 30 syphilis negative controls during a cohort study investigating syphilis biomarkers conducted at a sexually transmitted infection/HIV clinic in Antwerp, Belgium. Syphilis was diagnosed based on a simultaneous positive treponemal and non-treponemal assay result and/or positive serum PCR targeting polA. Specimens collected at visi

SUBMITTER: Osbak KK 

PROVIDER: S-EPMC7507855 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature