Association Between Episodic Memory and Genetic Risk Factors for Alzheimer's Disease in South Asians from the Longitudinal Aging Study in India-Diagnostic Assessment of Dementia (LASI-DAD).

ABSTRACT:

Background/objectives

Genetic factors play an important role in Alzheimer's disease (AD) and cognitive aging. However, it is unclear whether risk loci identified in European ancestry (EA) populations have similar effects in other groups, such as South Asians.

Design

We investigated the allelic distribution and cognitive associations of 56 known AD risk single-nucleotide polymorphisms (SNPs) identified from three EA genome-wide association studies (EA-GWASs) in a South Asian population. Single SNP and genetic risk score (GRS) associations with measures of episodic memory were assessed.

Setting

The Diagnostic Assessment of Dementia for the Longitudinal Aging Study in India (LASI-DAD).

Participants

A total of 906 LASI-DAD participants from diverse states in India.

SUBMITTER: Smith JA 

PROVIDER: S-EPMC7507858 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature