GPRC5D is a target for the immunotherapy of multiple myeloma with rationally designed CAR T cells.

ABSTRACT: Early clinical results of chimeric antigen receptor (CAR) T cell therapy targeting B cell maturation antigen (BCMA) for multiple myeloma (MM) appear promising, but relapses associated with residual low-to-negative BCMA-expressing MM cells have been reported, necessitating identification of additional targets. The orphan G protein-coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, was previously identified as expressed by mRNA in marrow aspirates from patients with MM, but confirmation of protein expression remained elusive. Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138⁺ MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA. Pann

SUBMITTER: Smith EL 

PROVIDER: S-EPMC7508042 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature