Programming Multifaceted Pulmonary T Cell Immunity by Combination Adjuvants.

ABSTRACT: Induction of protective mucosal T cell memory remains a formidable challenge to vaccinologists. Using a combination adjuvant strategy that elicits potent CD8 and CD4 T cell responses, we define the tenets of vaccine-induced pulmonary T cell immunity. An acrylic-acid-based adjuvant (ADJ), in combination with Toll-like receptor (TLR) agonists glucopyranosyl lipid adjuvant (GLA) or CpG, promotes mucosal imprinting but engages distinct transcription programs to drive different degrees of terminal differentiation and disparate polarization of T_H1/T_C1/T_H17/T_C17 effector/memory T cells. Combination of ADJ with GLA, but not CpG, dampens T cell receptor (TCR) signaling, mitigates terminal differentiation of effectors, and enhances the development of CD4 a

SUBMITTER: Marinaik CB 

PROVIDER: S-EPMC7508055 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature