Ammonium Salt-Catalyzed Ring-Opening of Aryl-Aziridines with β-Keto Esters.

ABSTRACT: We herein report an ammonium salt-catalyzed protocol for the regioselective ring opening of aryl-aziridines with β-keto esters. The reaction gives access to a variety of highly functionalized target molecules with two consecutive stereo-genic centers and can be rendered enantioselective (up to e.r. = 91:9) by using bifunctional chiral ammonium salt catalysts.

SUBMITTER: Haider V 

PROVIDER: S-EPMC7508174 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature