JAM-A Acts via C/EBP-α to Promote Claudin-5 Expression and Enhance Endothelial Barrier Function.

ABSTRACT:

Rationale

Intercellular tight junctions are crucial for correct regulation of the endothelial barrier. Their composition and integrity are affected in pathological contexts, such as inflammation and tumor growth. JAM-A (junctional adhesion molecule A) is a transmembrane component of tight junctions with a role in maintenance of endothelial barrier function, although how this is accomplished remains elusive.

Objective

We aimed to understand the molecular mechanisms through which JAM-A expression regulates tight junction organization to control endothelial permeability, with potential implications under pathological conditions.

Methods and results

Genetic deletion of JAM-A in mice significantly increased vascular permeability. This was associated with significantly decr

SUBMITTER: Kakogiannos N 

PROVIDER: S-EPMC7508279 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature