Excess crossovers impede faithful meiotic chromosome segregation in C. elegans.

ABSTRACT: During meiosis, diploid organisms reduce their chromosome number by half to generate haploid gametes. This process depends on the repair of double strand DNA breaks as crossover recombination events between homologous chromosomes, which hold homologs together to ensure their proper segregation to opposite spindle poles during the first meiotic division. Although most organisms are limited in the number of crossovers between homologs by a phenomenon called crossover interference, the consequences of excess interfering crossovers on meiotic chromosome segregation are not well known. Here we show that extra interfering crossovers lead to a range of meiotic defects and we uncover mechanisms that counteract these errors. Using chromosomes that exhibit a high frequency of supernumerary crossover

SUBMITTER: Hollis JA 

PROVIDER: S-EPMC7508374 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature