APOE ε4 and resting-state functional connectivity in racially/ethnically diverse older adults.

ABSTRACT:

Introduction

Numerous neuroimaging studies demonstrated an association between the apolipoprotein E (APOE) ε4 allele and resting-state functional connectivity (rsFC) of regions within the default mode network (DMN), both in healthy populations and patients with AD. It remains unclear whether the APOE ε4 allele differentially affects the brain's functional network architecture across race/ethnicity.

Methods

We investigated rsFC within DMN subsystems in 170 APOE ε4 carriers compared to 387 APOE ε4 non-carriers across three major racial/ethnic groups, including non-Hispanic Whites (n = 166), non-Hispanic Blacks (n = 185), and Hispanics (n = 206) from the Washington Heights-Inwood Columbia Aging Project.

Results

Compared to APOE ε4 non-c

SUBMITTER: Turney IC 

PROVIDER: S-EPMC7508460 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature