Rapid Increase of CTX-M-Producing Shigella sonnei Isolates in Switzerland Due to Spread of Common Plasmids and International Clones.

ABSTRACT: The Swiss Centre for Antibiotic Resistance (ANRESIS) has recently noted an increase of extended-spectrum cephalosporin-resistant (ESC-R) Shigella sonnei isolates nationwide (3.8% in 2016 versus 37.5% in 2019). To understand this phenomenon, we analyzed 25 representative isolates (of which 14 were ESC-R) collected in Switzerland during 2016 to 2019. Whole-genome sequencing was achieved using both the Illumina and the Nanopore platforms. Both ESC-R and extended-spectrum cephalosporin-susceptible isolates belonged to sequence type 152 (ST152). The ESC-R isolates carried bla_CTX-M-3 in IncI1-pST57 (n = 5), bla_CTX-M-15 in IncFII (F2:A-:B-) (n = 5), bla_CTX-M-15 in IncI1-pST16, and bla_CTX-M-27, bla<

SUBMITTER: Campos-Madueno EI 

PROVIDER: S-EPMC7508577 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature