Suboptimal Dosing of Fluconazole in Critically Ill Patients: Time To Rethink Dosing.

ABSTRACT: Fluconazole is frequently used for the treatment of invasive Candida infections in critically ill patients. However, alterations in renal functions might influence fluconazole clearance. Therefore, our objective was to study the impact of renal function on the population pharmacokinetics of fluconazole in critically ill patients with various degrees of renal function or undergoing continuous renal replacement therapy (CRRT). This was an open-label, multicenter observational study. Critically ill patients receiving fluconazole were included. Baseline and clinical data were collected. At days 3 and 7 of enrollment, blood samples were drawn for pharmacokinetic curves. Additionally, daily trough samples were taken. A nonlinear mixed-effects model was built, followed by Monte Carlo simul

SUBMITTER: Muilwijk EW 

PROVIDER: S-EPMC7508595 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature