Rifampicin Transport by OATP1B1 Variants.

ABSTRACT: Single nucleotide polymorphisms in the OATP1B1 transporter have been suggested to partially explain the large interindividual variation in rifampicin exposure. HEK293 cells overexpressing wild-type (WT) or OATP1B1 variants *1b, *4, *5, and *15 were used to determine the in vitro rifampicin intrinsic clearance. For OATP1B1*5 and *15, a 36% and 42% reduction in intrinsic clearance, respectively, compared to WT was found. We consider that these differences in intrinsic clearance most likely have minor clinical implications.

SUBMITTER: Litjens CHC 

PROVIDER: S-EPMC7508598 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature