The repertoire of Adhesion G protein-coupled receptors in adipocytes and their functional relevance.

ABSTRACT:

Background

G protein-coupled receptors (GPCR) are well-characterized regulators of a plethora of physiological functions among them the modulation of adipogenesis and adipocyte function. The class of Adhesion GPCR (aGPCR) and their role in adipose tissue, however, is poorly studied. With respect to the demand for novel targets in obesity treatment, we present a comprehensive study on the expression and function of this enigmatic GPCR class during adipogenesis and in mature adipocytes.

Methods

The expression of all aGPCR representatives was determined by reanalyzing RNA-Seq data and by performing qPCR in different mouse and human adipose tissues under low- and high-fat conditions. The impact of aGPCR expression on adipocyte differentiation and lipid accumulation was studied b

SUBMITTER: Suchy T 

PROVIDER: S-EPMC7508673 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature