Emerging drugs for treatment of focal segmental glomerulosclerosis.

ABSTRACT:

Background

Glomerulosclerosis represents the final stage of glomerular injury during the course of kidney disease and can result from a primary disturbance in disorders like focal segmental glomerulosclerosis or a secondary response to tubulointerstitial disease. Overall, primary focal glomerulosclerosis (FSGS), the focus of this review, accounts for 10-20% of patients of all ages who progress to end stage kidney disease. There are no FDA approved therapeutic options that effectively prevent or delay the onset of kidney failure.

Areas covered

Current immunosuppressive therapy and conservative management including inhibitors of the renin-angiotensin-aldosterone axis and sodium-glucose cotransporter are reviewed. FSGS is now recognized to represent a heterogeneous entity with

SUBMITTER: Trachtman H 

PROVIDER: S-EPMC7508791 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature