Racial and sex differences in the polymorphisms of the endocannabinoid receptor genes in obesity.

ABSTRACT:

Background

Obesity is a global epidemic and prevalence of obesity is higher in African Americans (AAs) compared to Caucasians. The endocannabinoid system (EC) and polymorphism in the endocannabinoid receptor type 1 (CNR1) gene 3813A/G and 4895A/G and in the fatty acid amide hydrolase (FAAH) are associated with obesity. The objective was to explore racial and sex differences in these polymorphisms and the biochemical abnormalities seen in obesity.

Methods

A cross-sectional study of 667 subjects (53.67% female; 49.18% AA; 69.72% were obese (body mass index [BMI] ≥30)) were screened for CNR1 3813, 4895 and FAAH 385 polymorphisms using a real-time polymerase chain reaction (PCR) system.

Results

Subjects with FAAH 385 polymorphisms were more likely to be obese (75.14% vs.

SUBMITTER: Thethi TK 

PROVIDER: S-EPMC7508856 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature