Anti-CD99 scFv-ELP nanoworms for the treatment of acute myeloid leukemia.
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ABSTRACT:
SUBMITTER: Vaikari VP
PROVIDER: S-EPMC7508895 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Publications
Anti-CD99 scFv-ELP nanoworms for the treatment of acute myeloid leukemia.
Vaikari Vijaya Pooja VP Park Mincheol M Keossayan Lena L MacKay J Andrew JA Alachkar Houda H
Nanomedicine : nanotechnology, biology, and medicine 20200612
CD99 is a transmembrane glycoprotein shown to be upregulated in various malignancies. We have previously reported CD99 to be highly upregulated and present a viable therapeutic target in acute myeloid leukemia (AML). Currently, no therapy against CD99 is under clinical investigation. As a surface molecule, CD99 can be targeted with an antibody-based approach. Here, we have developed a new modality to target CD99 by engineering a fusion protein composed of a single-chain variable fragment antibod ...[more]
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