Animal models of high-risk corneal transplantation: A comprehensive review.

ABSTRACT: Over the past century, corneal transplantation has become the most commonly performed allogeneic solid tissue transplantation. Although more than 80% of the corneal transplantations have favorable outcomes, immune-mediated rejection continues to be the major cause of failure in well over 50% of graft recipients that have inflamed and vascularized host beds. Over the past two decades, the progress in our understanding of the immunological pathways that mediate graft rejection has aided in the development of novel therapeutic strategies. In order to successfully test the efficacy of these interventions, it is essential to model the immunological processes occurring as a consequence of corneal transplantation. Herein, we have comprehensively reviewed the established animal models used for rep

SUBMITTER: Singh RB 

PROVIDER: S-EPMC7508940 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature