DTI-identified microstructural changes in the gray matter of mice overexpressing CRF in the forebrain.

ABSTRACT: Increased corticotroping releasing factor (CRF) contributes to brain circuit abnormalities associated with stress-related disorders including posttraumatic stress disorder. However, the causal relationship between CRF hypersignaling and circuit abnormalities associated with stress disorders is unclear. We hypothesized that increased CRF exposure induces changes in limbic circuit morphology and functions. An inducible, forebrain-specific overexpression of CRF (CRFOE) transgenic mouse line was used to longitudinally investigate its chronic effects on behaviors and microstructural integrity of several brain regions. Behavioral and diffusion tensor imaging studies were performed before treatment, after 3-4 wks of treatment, and again 3 mo after treatment ended to assess recovery. CRFOE was ass

SUBMITTER: Deslauriers J 

PROVIDER: S-EPMC7508966 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature