Maternal exercise conveys protection against NAFLD in the offspring via hepatic metabolic programming.

ABSTRACT: Maternal exercise (ME) during pregnancy has been shown to improve metabolic health in offspring and confers protection against the development of non-alcoholic fatty liver disease (NAFLD). However, its underlying mechanism are still poorly understood, and it remains unclear whether protective effects on hepatic metabolism are already seen in the offspring early life. This study aimed at determining the effects of ME during pregnancy on offspring body composition and development of NAFLD while focusing on proteomic-based analysis of the hepatic energy metabolism during developmental organ programming in early life. Under an obesogenic high-fat diet (HFD), male offspring of exercised C57BL/6J-mouse dams were protected from body weight gain and NAFLD in adulthood (postnatal day (P) 112). This

SUBMITTER: Bae-Gartz I 

PROVIDER: S-EPMC7508970 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature