Prognostic Implications of Metabolism Related Gene Signature in Cutaneous Melanoma.

ABSTRACT: Metabolic reprogramming is closely related to melanoma. However, the prognostic role of metabolism-related genes (MRGs) remains to be elucidated. We aimed to establish a nomogram by combining MRGs signature and clinicopathological factors to predict melanoma prognosis. Eighteen prognostic MRGs between melanoma and normal samples were identified using The Cancer Genome Atlas (TCGA) and GSE15605. WARS (HR = 0.881, 95% CI = 0.788-0.984, P = 0.025) and MGST1 (HR = 1.124, 95% CI = 1.007-1.255, P = 0.037) were ultimately identified as independent prognostic MRGs with LASSO regression and multivariate Cox regression. The MRGs signature was established according to these two genes and externally validated in the Gene Expression Omnibus (GEO) dataset. Kaplan-Meier surviv

SUBMITTER: Zeng F 

PROVIDER: S-EPMC7509113 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature