Chitosan-Coated Titanium Dioxide-Embedded Paclitaxel Nanoparticles Enhance Anti-Tumor Efficacy Against Osteosarcoma.

ABSTRACT:

Objective

Titanium dioxide nanoparticles (TiO₂) nanoparticles have been widely explored in the prevention of cancer risk. Due to the difficult solubility of TiO₂ nanoparticles, it is essential to synthesize new surfactants to increase its bioavailability and anti-tumor activity and reduce its cytotoxicity. Furthermore, oxidative and inflammation are closely associated with the osteosarcoma risk. Chitosan has biocompatibility, antioxidant and anti-inflammatory properties. The effects of chitosan-coated TiO₂-embedded paclitaxel nanoparticles on an osteosarcoma model were explored.

Methods

An osteosarcoma model was established and chitosan-coated TiO₂-embedded paclitaxel nanoparticles were prepared using a freeze-drying strategy. The

SUBMITTER: Qu Y 

PROVIDER: S-EPMC7509149 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature