A murine model of pediatric inflammatory bowel disease causes microbiota-gut-brain axis deficits in adulthood.

ABSTRACT: Inflammatory bowel diseases (IBDs) are chronic intestinal diseases, frequently associated with comorbid psychological and cognitive deficits. These neuropsychiatric effects include anxiety, depression, and memory impairments that can be seen both during active disease and following remission and are more frequently seen in pediatric patients. The mechanism(s) through which these extraintestinal deficits develop remain unknown, and the study of these phenomenon is hampered by a lack of murine pediatric IBD models. Herein we describe microbiota-gut-brain (MGB) axis deficits following induction of colitis in a pediatric setting. Acute colitis was induced by administration of 2% dextran sodium sulfate (DSS) for 5 days starting at weaning [postnatal day (P)21] causing reduced weight gain, colon

SUBMITTER: Salvo E 

PROVIDER: S-EPMC7509259 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature