Wnt Signaling Through Nitric Oxide Synthase Promotes the Formation of Multi-Innervated Spines.

ABSTRACT: Structural plasticity of synapses correlates with changes in synaptic strength. Dynamic modifications in dendritic spine number and size are crucial for long-term potentiation (LTP), the cellular correlate of learning and memory. Recent studies have suggested the generation of multi-innervated spines (MIS), in the form of several excitatory presynaptic inputs onto one spine, are crucial for hippocampal memory storage. However, little is known about the molecular mechanisms underlying MIS formation and their contribution to LTP. Using 3D enhanced resolution confocal images, we examined the contribution of Wnt synaptic modulators in MIS formation in the context of LTP. We show that blockage of endogenous Wnts with specific Wnt antagonists supresses the formation of MIS upon chemical LTP indu

SUBMITTER: McLeod F 

PROVIDER: S-EPMC7509412 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature