Novel Tunable Spatio-Temporal Patterns From a Simple Genetic Oscillator Circuit.

ABSTRACT: Multicellularity, the coordinated collective behavior of cell populations, gives rise to the emergence of self-organized phenomena at many different spatio-temporal scales. At the genetic scale, oscillators are ubiquitous in regulation of multicellular systems, including during their development and regeneration. Synthetic biologists have successfully created simple synthetic genetic circuits that produce oscillations in single cells. Studying and engineering synthetic oscillators in a multicellular chassis can therefore give us valuable insights into how simple genetic circuits can encode complex multicellular behaviors at different scales. Here we develop a study of the coupling between the repressilator synthetic genetic ring oscillator and constraints on cell growth in colonies. We sho

SUBMITTER: Yanez Feliu G 

PROVIDER: S-EPMC7509427 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature