A Computational Model of the Cholinergic Modulation of CA1 Pyramidal Cell Activity.

ABSTRACT: Dysfunction in cholinergic modulation has been linked to a variety of cognitive disorders including Alzheimer's disease. The important role of this neurotransmitter has been explored in a variety of experiments, yet many questions remain unanswered about the contribution of cholinergic modulation to healthy hippocampal function. To address this question, we have developed a model of CA1 pyramidal neuron that takes into consideration muscarinic receptor activation in response to changes in extracellular concentration of acetylcholine and its effects on cellular excitability and downstream intracellular calcium dynamics. This model incorporates a variety of molecular agents to accurately simulate several processes heretofore ignored in computational modeling of CA1 pyramidal neurons. These p

SUBMITTER: Mergenthal A 

PROVIDER: S-EPMC7509450 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature