Cytotoxic effect of Ginkgo biloba kernel extract on HCT116 and A2058 cancer cell lines.

ABSTRACT: While the pharmacology of Ginkgo biloba leaf extract has been studied extensively, little is known about the pharmacological potential of Ginkgo biloba seeds, although they contain similar active ingredients that are responsible for the therapeutic effects of the leaf extract. In this study we used 70%-methanol Ginkgo biloba kernel extract, quantified its bioactive constituents and tested their cytotoxic effect on two cancer cell lines, A2058 and HCT116, and the non-tumor cell line McCoy-Plovdiv. We studied the biological effect of the extract by real-time analysis in the xCELLigence system, WST-1 assay and LIVE/DEAD viability assay. We show that the extract significantly perturbed the viability of cancer cells in a concentration- and time-dependent manner. In contrast

SUBMITTER: Feodorova Y 

PROVIDER: S-EPMC7509470 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature