Long-Term Investigation of Retinal Function in Patients with Achromatopsia.

ABSTRACT:

Purpose

To investigate the long-term natural history of retinal function of achromatopsia (ACHM).

Methods

Subjects with molecularly confirmed ACHM were recruited in a prospective cohort study of mesopic microperimetry. Coefficient of repeatability and intraclass correlation coefficient (ICC) of mean sensitivity (MS) were calculated. Best-corrected visual acuity (BCVA), bivariate contour ellipse area (BCEA), contrast sensitivity (CS), MS, total volume (VTOT), and central field volume (V5°) from volumetric and topographic analyses were acquired. Correlation of functional parameters with structural findings from optical coherence tomography (OCT) was performed.

Results

Eighteen subjects were recruited. Mean follow-up was 7.2 years. The MS test-retest repeatability coeffi

SUBMITTER: Georgiou M 

PROVIDER: S-EPMC7509756 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature