Comparative transcriptomic profiling of myxomatous mitral valve disease in the cavalier King Charles spaniel.

ABSTRACT:

Background

Almost all elderly dogs develop myxomatous mitral valve disease by the end of their life, but the cavalier King Charles spaniel (CKCS) has a heightened susceptibility, frequently resulting in death at a young age and suggesting that there is a genetic component to the condition in this breed. Transcriptional profiling can reveal the impact of genetic variation through differences in gene expression levels. The aim of this study was to determine whether expression patterns were different in mitral valves showing myxomatous degeneration from CKCS dogs compared to valves from non-CKCS dogs.

Results

Gene expression patterns in three groups of canine valves resulted in distinct separation of normal valves, diseased valves from CKCS and diseased valves from other breeds

SUBMITTER: Markby GR 

PROVIDER: S-EPMC7509937 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature