Urinary AQP5 is independently associated with eGFR decline in patients with type 2 diabetes and nephropathy.

ABSTRACT:

Aims

Intrarenal Aquaporin 5 (AQP5) is upregulated in patients with diabetic nephropathy. Here we investigate whether urinary AQP5 is independently associated with estimated glomerular filtration rate (eGFR) decline in patients with type 2 diabetes and nephropathy.

Methods

Baseline urine samples (n = 997) from patients with type 2 diabetes and nephropathy of the sulodexide macroalbuminuria trial were measured for AQP5 through enzyme-linked immunosorbent assays. Pearson correlation and multiple linear regression between AQP5 with eGFR slope (calculated by ≥3 serum creatinine during follow-up) was performed, and association with fast renal function decline, defined as eGFR slope less than 3.0 mL/min/1.73 m²/year, was determined by logistic regression.

Results

SUBMITTER: Gao C 

PROVIDER: S-EPMC7509983 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature