Clinical Parameters, Fuel Oxidation, and Glucose Kinetics in Patients With Type 2 Diabetes Treated With Dapagliflozin Plus Saxagliptin.

ABSTRACT:

Objective

To examine the mechanisms responsible for improved glycemia with combined sodium-glucose cotransporter 2 inhibitor (SGLT2i) plus dipeptidyl peptidase 4 inhibitor therapy in type 2 diabetes.

Research design and methods

Fifty-six patients (HbA_1c 8.9 ± 0.2% [74 ± 2 mmol/mol]) were randomized to dapagliflozin (DAPA) 10 mg, DAPA/saxagliptin (SAXA) 10/5 mg, or placebo (PCB) for 16 weeks. Basal endogenous glucose production (EGP) (3-³H-glucose), urinary glucose excretion, glucose/lipid oxidation, HbA_1c, and substrate/hormone levels were determined before treatment (Pre-Tx) and after treatment (Post-Tx).

Results

At week 16, HbA_1c decrease was greater (P < 0.05) in DAPA/SAXA (-2.0 ± 0.3%) vs. DAPA (-1.4 ± 0.2%) and g

SUBMITTER: Qin Y 

PROVIDER: S-EPMC7510028 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature