Improved Detection of Abnormal Glucose Tolerance in Africans: The Value of Combining Hemoglobin A_1c With Glycated Albumin.

ABSTRACT:

Objective

In African-born Blacks living in America, we determined by BMI category 1) prevalence of abnormal glucose tolerance (Abnl-GT) and 2) diagnostic value and reproducibility of hemoglobin A_1c (HbA_1c), fructosamine, and glycated albumin (GA).

Research design and methods

Participants (n = 416; male, 66%; BMI 27.7 ± 4.5 kg/m² [mean ± SD]) had an oral glucose tolerance test with HbA_1c, GA, and fructosamine assayed. These glycemic markers were repeated 11 ± 7 days later. Abnl-GT diagnosis required 0 h ≥5.6 mmol/L (≥100 mg/dL) and/or 2 h ≥7.8 mmol/L (≥140 mg/dL). Thresholds for HbA_1c, GA, and fructosamine were the values at the 75th percentile for the population (39 mmol/mol [5.7%], 14.2%, and 234 μm

SUBMITTER: Hobabagabo AF 

PROVIDER: S-EPMC7510044 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature