Non-invasive measurement of choroid plexus apparent blood flow with arterial spin labeling.

ABSTRACT:

Background

The choroid plexus is a major contributor to the generation of cerebrospinal fluid (CSF) and the maintenance of its electrolyte and metabolite balance. Here, we sought to characterize the blood flow dynamics of the choroid plexus using arterial spin labeling (ASL) MRI to establish ASL as a non-invasive tool for choroid plexus function and disease studies.

Methods

Seven healthy volunteers were imaged on a 3T MR scanner. ASL images were acquired with 12 labeling durations and post labeling delays. Regions of the choroid plexus were manually segmented on high-resolution T₁ weighted images. Choroid plexus perfusion was characterized with a dynamic ASL perfusion model. Cerebral gray matter perfusion was also quantified for comparison.

Results

Kinetics

SUBMITTER: Zhao L 

PROVIDER: S-EPMC7510126 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature